Program-Specific Required Courses
Kredi: 3
The aim of this course is to introduce the recognition of antigen, its role and role of MHC, immune receptors and signaling pathways, development of lymphocytes, adaptive immune system principles, mechanisms of effector immune responses, newly defined cells and signaling pathways and new developments in immunology. Students will prepare a presentation for scheduled topic.
Kredi: 3
Introduce the recognition of antigen, its role and role of MHC, immune receptors and signaling pathways, development of lymphocytes, adaptive immune system principles, mechanisms of effector immune responses, newly defined cells and signaling pathways and new developments in immunology.
Kredi: 3
The aim of this course is to teach the principles of the immune system in detail in health and disease immunology and to explain the immunological mechanisms in detail. Specialized topics such as infection immunology, allergy, hypersensitivity responses, immunodeficiencies, transplantation immunology, autoimmunity mechanisms, and tumor immunology will be discussed. Students will prepare a presentation for each scheduled topic and the lesson will be interactive with the discussion of each topic.
Kredi: 0
This course is non-credit and aims to increase scientific interaction between students and improve students’ presentation skills by ensuring the participation of students from all interdisciplinary programs. The seminar course, which consists of the presentation of the studies and research conducted in front of the community within the framework of the techniques determined with the guidance of the advisor and the question and answer section, is graded periodically as S/U by the program coordinators. The course must be taken at least once and completed successfully within the framework of Council of Higher Education rules. Program-specific rules are determined by program coordinators and shared with students.
Kredi: 0
This course is non-credit and is a course in which the advisor evaluates the student’s thesis work. It covers all the studies and research to be carried out on the thesis topic determined with the guidance of the advisor and is graded periodically as S/U by the advisor faculty member.
Kredi: 0
This course is non-credit and is a course in which the advisor evaluates the student’s work. It covers all the studies and research to be carried out on the project topic determined with the guidance of the advisor and is graded periodically as S/U by the advisor faculty member. It is sufficient to take it only in the last semester of project writing.
General Required Courses
Credit:3
Ethical principles in biomedical research, biosafety, ethics in animal studies, human and patients’ rights, ethics in clinical research, national and international examples in publication ethics and principles will be discussed. Course will be completed via CITI online education program.
Credit: 3
An introduction to important topics in biostatistical concepts and reasoning. Tools for describing central tendency and variability in data; methods for performing inference on population means and proportions via sample data; statistical hypothesis testing and its application to group comparisons. Several statistical methods such as linear regression, ANOVA, logistic regression, survival analysis, nonparametric methods, ROC analysis that are commonly used to study biological problems. In-lab practices on computers and software for statistical analysis, to provide students with the skills to generate, read and interpret the results in their fields of study.
Credit: 0
Foundations and basics of designing effective teaching environments for higher education courses, learning principles, teaching in English, integrating learning technologies into teaching practices, grading, communicating with students and instructors, and superdiversity and gender sensitive pedagogy.
Credit: 0
The following objectives will be met through extensive reading, writing and discussion both in and out of class.Build a solid background in academic discourse, both written and spoken. Improve intensive and extensive critical reading skills. Foster critical and creative thinking. Build fundamental academic writing skills including summary, paraphrase, analysis, synthesis. Master cohesiveness as well as proper academic citation when incorporating the work of others.
Program-Specific Elective Courses
Kredi: 3
This course aims to provide students with knowledge and understanding of the role of immunological mechanisms in the development and treatment of diseases. Clinician-scientists will explain the course, and the topics will be covered through diseases that are their research areas. The topics will be handled interactively with new literature.
Kredi: 3
This course aims to explain the immunological mechanisms involved in the pathogenesis of infections and pathogen-related virulence factors, the molecular epidemiology of infections and the mechanisms of resistance to antimicrobial therapies. The course will be interactive with a predominantly focused education model and will be supported by discussions of articles on the agenda.
Kredi: 3
Basic and specific allergic immune mechanisms like interaction of environmental & genetic factors, epithelial barrier function, Innate and adaptive immunity cells, tolerance mechanisms, airway inflammation in asthma and allergic rhinitis, IgE /non-IgE-mediated inflammation in food & drug allergy, skin inflammation in eczema, urticaria.
Kredi: 3
This course will start with a discussion of the unique immunity of the nervous system at the anatomical and cellular level together with the basics of the development of immune reactions in the central and peripheral nervous systems. After that, pathogenesis, clinical features, biomarker studies and current state-of the art of diagnostic procedures and treatment of the autoimmune neurological diseases will be discussed. In addition, recent studies on the relationship between neuroinflammation and neurodegeneration will be covered in terms of methods, major findings, and reflections on treatment.
Kredi: 3
The Transplant Immunology course will shed light on the different mechanisms involved in the recipient’s post-transplant adaptive and innate alloimmunity against solid organs, tissues and cells culminating into either graft tolerance or graft (acute or chronic) rejection. Another aspect of this course is to identify bottlenecks in the comprehension of the immunological interface between rejection of solid organs after transplantation and posttransplant clinical complications. In addition to immunosuppression, mechanisms pertaining to desensitization and tolerance induction will be taught. This will enable us to provide the state-of-the-art of novel approaches aiming to better monitor the transplanted graft for improved graft and patient outcomes. To that end, students will be required to select, present and discuss one new method involved in either pre transplantation organ desensitization or post transplantation induction of long-term organ tolerance. Furthermore, we will provide a profound and multidisciplinary explanation of assessment techniques to work out the eligibility of donor and recipient. The overarching goal is to build a solid understanding of transplantation immunity leading to discovery research that expedites the development of new therapies for transplant recipients.
Kredi: 3
The aim of this course is to discuss the roles of the cells of the immune system in cancer and antitumor immunity. The course will begin with an introduction to cancer immunology and continue to discuss tumor microenvironment and progression, innate and adaptive immunity in cancer focusing on the roles of Natural Killer Cells, Natural Killer T cells, Dendritic cells, Granulocytes, B-lymphocytes and T-lymphocytes and include tumor-induced T cell dysfunction. Cytokines, Chemokines and Chemokine receptors, Major Histocompatibility Complex molecules in cancer progression and tumor immunity and the concept of cancer immunoediting will be covered in the second part. Students will make a presentation of a journal article on the concepts covered in the course before the final examination.
Kredi: 3
The critical function of the immune system is to distinguish self from non-self. In this course, the tolerance mechanisms, the cells that play a role in the development of tolerance, the mechanisms of the breakdown of tolerance, the role of genetic and environmental factors in the development of autoimmunity, and the mechanisms involved in the development of autoimmune diseases and pathogenesis, their animal models, autoinflammatory diseases and hypersensitivity responses will be explained. Topics will be discuss interactively with new literature.
Kredi: 3
Introduction to metabolic pathways and immune system / Immunometabolism. Glucose metabolism and immunity. Adipose tissue and immune system. Fatty acid oxidation and synthesis and Immune function. Mitochondrial Metabolism and Oxidative Stress. The pentose phosphate pathway and immune system. The tricarboxylic acid (TCA) cycle and immune system. Amino acid metabolism and immune system. Diabetes Mellitus and immune system. Metabolic Syndrome, obesity and immune system. Immunometabolism and autoimmunity. Immunometabolism in the brain. Sex Differences in Immunometabolism. Immunometabolism and Immunotherapy.
Kredi: 3
Theoretical and practical knowledge in immunologic techniques. The principles, technicalities, and application of flow cytometry. Panel design and selection of the right colours for bright and dim CD immunology markers. How cytokine staining and T cell proliferation experiments are executed. Knowhow pertaining to (donor specific) HLA antibodies and their relevance in organ transplantation. Tissue typing in the lab dedicated for organ transplantation. The theoretical and practical knowledge about indirect immunofluorescence assays. ELISA and Elispot applications.
Kredi: 3
This course is a special course given by the student’s advisor for the student’s thesis work. The PhD students who enrolled with a BS degree can count 2 Independent Study course credits, and the PhD students who enrolled with an MS degree and MS students can count 1 Independent Study course credit during the education period. The important thing is that the Independent Study course names and contents that you take must be different to count the credits.
