IMMN 501 / BASIC CONCEPTS OF IMMUNOLOGY
Sınıf: Credit: 3Precondition:

The aim of this course is to introduce the recognition of antigen, its role and role of MHC, immune receptors and signaling pathways, development of lymphocytes, adaptive immune system principles, mechanisms of effector immune responses, newly defined cells and signaling pathways and new developments in immunology. Students will prepare a presentation for scheduled topic. The assessment of the students will be done according to their final examination and performances in presentations and participation to scientific discussion.

IMMN 502 / FUNDAMENTAL IMMUNOLOGY
Sınıf: Credit: 3Precondition:

Introduce the recognition of antigen, its role and role of MHC, immune receptors and signaling pathways, development of lymphocytes, adaptive immune system principles, mechanisms of effector immune responses, newly defined cells and signaling pathways and new developments in immunology.

IMMN 503 / IMMUNE SYSTEM IN HEALTH&DISEAS
Sınıf: Credit: 3Precondition: IMMN 501 and IMMN 502

The aim of this course is to teach the principles of the immune system in detail in health and disease immunology and to explain the immunological mechanisms in detail. Specialized topics such as infection immunology, allergy, hypersensitivity responses, immunodeficiencies, transplantation immunology, autoimmunity mechanisms, and tumor immunology will be discussed. Students will prepare a presentation for each scheduled topic and the lesson will be interactive with the discussion of each topic.

IMMN 504 / ADVANCE CLINICAL IMMUNOLOGY
Sınıf: Credit: 3Precondition: IMMN 501 and IMMN 502

This course aims to provide students with knowledge and understanding of the role of immunological mechanisms in the development and treatment of diseases. Clinician-scientists will explain the course, and the topics will be covered through diseases that are their research areas. The topics will be handled interactively with new literature. Students will be assessed based on their final exams and their performance in presentations and their participation in the scientific discussion.

IMMN 505 / INFECTION&IMMUNITY
Sınıf: Credit: 3Precondition: IMMN 501 and IMMN 502

This course aims to explain the immunological mechanisms involved in the pathogenesis of infections and pathogen-related virulence factors, the molecular epidemiology of infections and the mechanisms of resistance to antimicrobial therapies. The course will be interactive with a predominantly focused education model and will be supported by discussions of articles on the agenda.

IMMN 506 / ALLERGY&HYPERSENSITIVITY REACT
Sınıf: Credit: 3Precondition: IMMN 501 and IMMN 502

Basic and specific allergic immune mechanisms like interaction of environmental & genetic factors, epithelial barrier function, Innate and adaptive immunity cells, tolerance mechanisms, airway inflammation in asthma and allergic rhinitis, IgE /non-IgE-mediated inflammation in food & drug allergy, skin inflammation in eczema, urticaria.

IMMN 507 / NEUROIMMUNOLOGY&NEUROINFLAMMAT
Sınıf: Credit: 3Precondition: IMMN 501 and IMMN 502

This course will start with a discussion of the unique immunity of the nervous system at the anatomical and cellular level together with the basics of the development of immune reactions in the central and peripheral nervous systems. After that, pathogenesis, clinical features, biomarker studies and current state-of the art of diagnostic procedures and treatment of the autoimmune neurological diseases will be discussed. In addition, recent studies on the relationship between neuroinflammation and neurodegeneration will be covered in terms of methods, major findings, and reflections on treatment.

IMMN 508 / TRANSPLANTATION IMMUNOLOGY
Sınıf: Credit: 3Precondition: IMMN 501 and IMMN 502

The Transplant Immunology course will shed light on the different mechanisms involved in the recipient’s post-transplant adaptive and innate alloimmunity against solid organs, tissues and cells culminating into either graft tolerance or graft (acute or chronic) rejection. Another aspect of this course is to identify bottlenecks in the comprehension of the immunological interface between rejection of solid organs after transplantation and posttransplant clinical complications. In addition to immunosuppression, mechanisms pertaining to desensitization and tolerance induction will be taught. This will enable us to provide the state-of-the-art of novel approaches aiming to better monitor the transplanted graft for improved graft and patient outcomes. To that end, students will be required to select, present and discuss one new method involved in either pre transplantation organ desensitization or post transplantation induction of long-term organ tolerance. Furthermore, we will provide a profound and multidisciplinary explanation of assessment techniques to work out the eligibility of donor and recipient. The overarching goal is to build a solid understanding of transplantation immunity leading to discovery research that expedites the development of new therapies for transplant recipients.

IMMN 509 / CANCER IMMUNOLOGY
Sınıf: Credit: 3Precondition: IMMN 501 and IMMN 502

The aim of this course is to discuss the roles of the cells of the immune system in cancer and antitumor immunity. The course will begin with an introduction to cancer immunology and continue to discuss tumor microenvironment and progression, innate and adaptive immunity in cancer focusing on the roles of Natural Killer Cells, Natural Killer T cells, Dendritic cells, Granulocytes, B-lymphocytes and T-lymphocytes and include tumor-induced T cell dysfunction. Cytokines, Chemokines and Chemokine receptors, Major Histocompatibility Complex molecules in cancer progression and tumor immunity and the concept of cancer immunoediting will be covered in the second part. Students will make a presentation of a journal article on the concepts covered in the course before the final examination.

IMMN 510 / TOLERANCE&AUTOIMMUNITY
Sınıf: Credit: 3Precondition: IMMN 501 and IMMN 502

The critical function of the immune system is to distinguish self from non-self. In this course, the tolerance mechanisms, the cells that play a role in the development of tolerance, the mechanisms of the breakdown of tolerance, the role of genetic and environmental factors in the development of autoimmunity, and the mechanisms involved in the development of autoimmune diseases and pathogenesis, their animal models, autoinflammatory diseases and hypersensitivity responses will be explained. Topics will be discuss interactively with new literature. Students will be assessed based on their final exams and their performance in presentations and their participation in the scientific discussion.