Blood-Brain Barrier Studies Laboratory

Studies are conducted by Prof.Dr. Mehmet Kaya.

Professor Kaya, who has been conducting research on the morphology, physiology, and pathology of barrier-type cerebral blood vessels in experimental animal models of diseases such as epilepsy, hypertensive encephalopathy, septic encephalopathy, and traumatic brain injury since 1985, has recently been working on barrier-type blood vessels in addition to his in vivo studies. It also examines the behavior of endothelial cells in vitro.

Molecular Hematophysiology Laboratory

Studies are conducted by Prof.Dr. Özlem Yalçın.

Prof. Dr. Özlem Yalçın completed her Ph.D. in “Medical Physiology” at Akdeniz University Health Sciences Institute in 2007, received the title of “Associate Professor” in 2014 and “Professor” in 2020. The main focus areas of Dr. Yalçın and her team are; application of deep learning techniques in hematological diagnosis, development of microfluidic-based tests that rapidly assess hemostatic function, fluid mechanics in the vasculature, mechanisms for local regulation of blood flow in tissues, and remote cell death of electrically excitable cancer cells by photo-active polymers.


RBCDEFSS: Regulation of erythrocyte deformability

Özlem Yalçın and her team investigate the effects of hemorheological properties on the circulatory system in detail. These studies examine the circulatory system for pathophysiological conditions like anemia and polycythemia. The team’s long-term goal is to investigate the erythrocyte factors that can affect the local regulation of the circulation and to elucidate their pathophysiological consequences. Thus, the mechanisms of erythrocyte-related problems will be identified in disorders such as coronary artery disease, arteriosclerosis, sickle cell anemia, inflammatory bowel disease, cardiac syndrome X, ischemic shock, and congenital heart disease.

MICROTEM: Microfluidic Thromboelastometer Device

This device has a technology that can increase the chance of the survival of one-third of the patients with active bleeding and bleeding disorders by up to 100 percent. The device works on a microfluidic basis and can analyze coagulation pathways rapidly. Thus, a detailed evaluation of the coagulation pathways is possible for patients with bleeding and bleeding disorders to determine the source of bleeding very quickly. The widespread use of the device will minimize bleeding and transfusion-related complications.

E-DeepSmartAnemia: A mobile app for anemia screening

This project aims to determine the risk of anemia with a non-invasive methodology by taking a photograph with a smartphone. The project involves the development of an algorithm that can analyze the photographic samples of different patient groups.

iCTEP: Strategies for Innovative Cancer Therapy

Cancer treatment is another research topic of the team. Two different studies are carried out in this area:

-In the first project, photo-electrical stimulation of voltage-gated ion channels is aimed to ensure cell death in electrically excitable cancer cells. This unique technology has all the advantages of photodynamic therapy and radiotherapy with low invasiveness and wireless remote treatment capabilities. It also requires less light power to provoke the cell stimulation and cell death mechanisms. The triggering mechanism of cell death is based on generating electrical charges in the cell membrane by light stimulation. It does not require the presence of chemical/enzymatic reactions or oxygen as in photothermal therapy or radiotherapy.

-Nanotechnology has entered all areas of our lives with its utilization in cancer treatment by enhancing the cell response to chemotherapy. The team’s second project aims to produce nano-carrier platforms for cancer cells resistant to chemotherapeutic agents and enable cells to respond to chemotherapy. The purpose of this study is to increase the efficiency of chemotherapy by identifying target proteins that are responsible for drug resistance.

Neurophysiology, EEG-ERP MakeLab Laboratories

Studies are conducted by Prof.Dr. Sacit Karamürsel and Asst. Prof. Dr. Ezgi Tuna Erdoğan.

The main research interest in our laboratories is electroneurophysiology. We mainly conduct research on healthy volunteers or patients.

Our main research topics are:

– Application of tDCS (transcranial Direct Current Stimulation) for the modulation of cerebral and cerebellar cortical networks for improving cognitive and sportive abilities, treatment, and rehabilitation of stroke and headache/migraine patients.

– Motor and sensory Cortical Mapping in order to protect important cortical areas before epilepsy surgery within the framework of our joint project with Koç University School of Medicine, Department of Neurology, and University of Houston Biomedical Department. For this purpose, we develop and use HFO (High-Frequency Oscillations) analysis as well as electrical stimulation, which is the gold standard for locating important motor and sensory areas and epileptic focus.

-CCEP (Cortico Cortical Evoked Potentials) recording and analysis are also in our area of ​​interest. Inhibition of seizure activity by stimulation with tDCS or implanted cortical DCS electrodes is our secondary goal.

– We design new electrodes and develop new stimulation techniques to prevent seizure activity.

– We perform IONM (IntraOperative Neuro-Monitorization) in Critical Neurosurgery cases.